Why the study?
Do verapamil and diltiazem inhibit human platelet function in vitro?
Population
Platelets from 20 random aspirin-abstaining human donors
Comparison
Verapamil and diltiazem (0.01-10 microM) vs Equimolar concentrations of each other and control
Design
Preclinical
Authors
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Hypothesis-generating for platelet effects in animals; leaves open human in vitro and clinical relevance.
Do verapamil and diltiazem inhibit human platelet function in vitro?
Verapamil and diltiazem specifically inhibit epinephrine-induced platelet activation in vitro, with verapamil demonstrating greater potency likely due to alpha-adrenergic receptor blockade.
Addonizio et al. (1986) studied this question.
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