Key result
Clopidogrel significantly decreased platelet function in healthy cats as detected by Platelet Function Analyzer 100 and Plateletworks, whereas aspirin showed minimal effects.
Why the study?
Do aspirin and clopidogrel reduce platelet function in healthy cats as measured by point-of-care tests?
Population
36 healthy facility-owned, non-pedigreed cats, mean age 6 years (range 3-12 years)
Comparison
Aspirin 5 mg q72h, aspirin 20.25 mg q72h, or… vs Baseline platelet function before treatment
Design
Preclinical, Randomly assigned to one of three treatment groups, with males…
Follow-up
8 days
Authors
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Supports PFA-100/Plateletworks for feline antiplatelet research; leaves open clinical translation in heart disease.
RCT (n=36)
Computerized method
No
Do aspirin and clopidogrel reduce platelet function in healthy cats as measured by point-of-care tests?
p-value: p=<0.05
Point-of-care tests like PFA-100 and Plateletworks can detect decreased platelet function in response to clopidogrel in cats, suggesting utility for monitoring antiplatelet therapy in feline heart disease.
Ho et al. (2016) conducted an RCT in Healthy cats (n=36). Aspirin and/or Clopidogrel vs. Baseline was evaluated on Decreased platelet function detected by Multiplate, PFA-100, and Plateletworks (p=<0.05). Clopidogrel significantly decreased platelet function in healthy cats as detected by Platelet Function Analyzer 100 and Plateletworks, whereas aspirin showed minimal effects.
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