Why the study?
Do different platelet function tests (Multiplate, PFA-200, Plateletworks) detect the effects of aspirin, clopidogrel, or combination therapy in healthy dogs?
Population
6 healthy laboratory Beagles
Comparison
Aspirin 1 mg/kg, clopidogrel 2 mg/kg, or… vs Placebo
Design
Preclinical, Randomized, Double-blind
Follow-up
1 week per phase
Key result
All three platelet function tests detected treatment effects of aspirin and clopidogrel in healthy dogs, with Plateletworks using arachidonic acid detecting significant decreases in aggregation (e.g., 80% to 7% with aspirin, p<0.001) in all dogs.
Authors
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Platelet function tests may detect antiplatelet effects in healthy dogs; leaves open validation for clinical monitoring or diseased patients.
RCT (n=6)
Double-blind
Randomized crossover design
No
Do different platelet function tests (Multiplate, PFA-200, Plateletworks) detect the effects of aspirin, clopidogrel, or combination therapy in healthy dogs?
Absolute Event Rate: 7% vs 80%
p-value: p=<0.001
Multiplate, PFA-200, and Plateletworks can detect the antiplatelet effects of aspirin and clopidogrel in healthy dogs, suggesting utility for monitoring therapy.
Saati et al. (2017) conducted an RCT in Healthy (n=6). Aspirin, clopidogrel, or combination therapy vs. Baseline (Day 0) was evaluated on Platelet aggregation using Plateletworks with arachidonic acid (PW AA) after 7 days of aspirin (p=<0.001). All three platelet function tests detected treatment effects of aspirin and clopidogrel in healthy dogs, with Plateletworks using arachidonic acid detecting significant decreases in aggregation (e.g., 80% to 7% with aspirin, p<0.001) in all dogs.
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