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February 1, 2016American Journal of Veterinary Research

13 of 16 dogs had turbidimetric and conventional impedance aggregometry results decreased by > 25% from baseline on days 3 and 7, and median urine 11-dehydro-thromboxane B2 concentration-to-creatinine ratio decreased by 49% between days 1 and 7.

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Why the study?

Does a low-dose aspirin regimen reduce platelet function in healthy dogs?

Population

16 healthy dogs

Comparison

Aspirin (1 mg/kg, PO, q 24 h) for 7 days vs Baseline (day 1, before aspirin administration)

Design

Preclinical

Follow-up

7 days

Authors

JHJillian M. HainesJTJohn M. ThomasonESEileen C. Seage

Discussion

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Overview

Variable aspirin response in healthy dogs with poor assay agreement; leaves open optimal monitoring before clinical use.

Structured PICO

Does a low-dose aspirin regimen reduce platelet function in healthy dogs?

P
Population
16 healthy dogs
I
Intervention
Aspirin (1 mg/kg, PO, q 24 h) for 7 days
C
Comparator
Baseline (day 1, before aspirin administration)
O
Outcome
Platelet function evaluated by turbidimetric and conventional impedance aggregometry, multiple-electrode impedance aggregometry, platelet function analyzer (PFA), and urine 11-dehydro-thromboxane B2 concentrationsurrogate

The response to a low-dose aspirin regimen varies among healthy dogs, and different platelet function assays show poor agreement in detecting aspirin-induced dysfunction.

Cite This Study

Haines et al. (2016) studied this question.

synapsesocial.com/papers/6a8a916a51cd0cd12ac15a4ehttps://doi.org/10.2460/ajvr.77.2.174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs2017 · 20 citations
  2. 2Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin2012 · 42 citations
  3. 3Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs2011 · 20 citations
  4. 4Influence of treatment with ultralow-dose aspirin on platelet aggregation as measured by whole blood impedance aggregometry and platelet P-selectin expression in clinically normal dogs2010 · 28 citations
  5. 5Effects of Aspirin and Prednisone on Platelet Function and Thromboxane Synthesis in Healthy Dogs2019 · 4 citations