What is the clinical evidence from this study?

Study design: Other. Population: Healthy dogs (n=20). Intervention: Aspirin vs. Baseline. Primary outcome: Urinary 11-dehydro-thromboxane B(2) and 2,3-dinorTXB(2) concentrations.

August 1, 2011American Journal of Veterinary Research

Aspirin at 1 mg/kg/d did not significantly decrease urinary 11-dehydroTXB(2) concentration in healthy dogs, suggesting this dosage may be insufficient for reliable platelet inhibition.

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Why the study?

Does aspirin administration reduce urinary thromboxane metabolites in healthy dogs?

Population

20 healthy dogs

Comparison

Aspirin 1 mg/kg PO q 24 h for 7 consecutive… vs Baseline (prior to aspirin administration)

Design

Preclinical

Follow-up

7 days (first phase) and single dose after 5-month washout

Key result

Aspirin at 1 mg/kg/d did not significantly decrease urinary 11-dehydroTXB(2) concentration in healthy dogs, suggesting this dosage may be insufficient for reliable platelet inhibition.

Authors

CHCrystal M. Hoh SSStephanie A. Smith JBJulie K. Byron

Discussion

Member takes

Overview

Questions efficacy of 1 mg/kg/d aspirin for platelet inhibition in dogs; leaves open optimal dosing for clinical use.

Structured PICO

Does aspirin administration reduce urinary thromboxane metabolites in healthy dogs?

Population

20 healthy dogs evaluated for urinary thromboxane metabolite responses to 1 mg/kg/d and 10 mg/kg aspirin dosages.

Intervention

Aspirin 1 mg/kg PO q 24 h for 7 consecutive doses, followed by a 5-month washout period, then a single dose of aspirin 10 mg/kg PO (in 10 dogs)

Comparator

Baseline (prior to aspirin administration)

Outcome

Urinary 11-dehydro-thromboxane B(2) [11-dehydroTXB(2)] and 2,3-dinorTXB(2) concentrations normalized to urine creatininesurrogate

Aspirin at 1 mg/kg/day may be insufficient for reliable platelet inhibition in healthy dogs based on urinary thromboxane metabolite levels.

Cite This Study

Hoh et al. (2011) studied Healthy dogs (n=20). Aspirin vs. Baseline was evaluated on Urinary 11-dehydro-thromboxane B(2) and 2,3-dinorTXB(2) concentrations. Aspirin at 1 mg/kg/d did not significantly decrease urinary 11-dehydroTXB(2) concentration in healthy dogs, suggesting this dosage may be insufficient for reliable platelet inhibition.

synapsesocial.com/papers/6a96c7cad565115f2b577ba0 https://doi.org/10.2460/ajvr.72.8.1038

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August 1, 2011American Journal of Veterinary Research

Aspirin at 1 mg/kg/d did not significantly decrease urinary 11-dehydroTXB(2) concentration in healthy dogs, suggesting this dosage may be insufficient for reliable platelet inhibition.

View Full Paper

Ask AI

Bookmark

Why the study?

Does aspirin administration reduce urinary thromboxane metabolites in healthy dogs?

Population

20 healthy dogs

Comparison

Aspirin 1 mg/kg PO q 24 h for 7 consecutive… vs Baseline (prior to aspirin administration)

Design

Preclinical

Follow-up

7 days (first phase) and single dose after 5-month washout

Key result

Aspirin at 1 mg/kg/d did not significantly decrease urinary 11-dehydroTXB(2) concentration in healthy dogs, suggesting this dosage may be insufficient for reliable platelet inhibition.

Authors

CHCrystal M. Hoh SSStephanie A. Smith JBJulie K. Byron

Discussion

Member takes

Overview

Questions efficacy of 1 mg/kg/d aspirin for platelet inhibition in dogs; leaves open optimal dosing for clinical use.

Structured PICO

Does aspirin administration reduce urinary thromboxane metabolites in healthy dogs?

Population

20 healthy dogs evaluated for urinary thromboxane metabolite responses to 1 mg/kg/d and 10 mg/kg aspirin dosages.

Intervention

Aspirin 1 mg/kg PO q 24 h for 7 consecutive doses, followed by a 5-month washout period, then a single dose of aspirin 10 mg/kg PO (in 10 dogs)

Comparator

Baseline (prior to aspirin administration)

Outcome

Urinary 11-dehydro-thromboxane B(2) [11-dehydroTXB(2)] and 2,3-dinorTXB(2) concentrations normalized to urine creatininesurrogate

Aspirin at 1 mg/kg/day may be insufficient for reliable platelet inhibition in healthy dogs based on urinary thromboxane metabolite levels.

Cite This Study

synapsesocial.com/papers/6a96c7cad565115f2b577ba0 https://doi.org/10.2460/ajvr.72.8.1038

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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