May 7, 2016Journal of Veterinary Internal MedicineOpen Access

The Effects of Cyclosporine and Aspirin on Platelet Function in Normal Dogs

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Why the study?

Does combined low-dose aspirin and cyclosporine inhibit cyclosporine-associated thromboxane synthesis without altering the antiplatelet effects of aspirin in healthy dogs?

Population

7 healthy dogs

Comparison

Combined low-dose aspirin and cyclosporine vs Low-dose aspirin, high-dose aspirin, and…

Design

Preclinical, randomized

Follow-up

7 days

Authors

JTJohn M. ThomasonNOAA National Marine Fisheries Service TATodd ArcherCarolina Veterinary Specialists RWRobert W. WillsMississippi State University

Discussion

Member takes

Implication

May attenuate cyclosporine platelet effects in dogs; hypothesis-generating, requires prospective validation before any clinical translation.

Structured PICO

Does combined low-dose aspirin and cyclosporine inhibit cyclosporine-associated thromboxane synthesis without altering the antiplatelet effects of aspirin in healthy dogs?

Population

7 healthy dogs

Intervention

Combined low-dose aspirin (1 mg/kg PO q24h) and cyclosporine (10 mg/kg PO q12h)

Comparator

Low-dose aspirin (1 mg/kg PO q24h), high-dose aspirin (10 mg/kg PO q12h), and cyclosporine (10 mg/kg PO q12h) alone in a crossover design

Outcome

Platelet function evaluated by turbidimetric aggregometry amplitude and platelet function analyzer closure time, and urine 11-dehydro-thromboxane-B2 (11-dTXB2)-to-creatinine ratio on days 3 and 7surrogate

In healthy dogs, low-dose aspirin inhibits cyclosporine-induced thromboxane synthesis without compromising the antiplatelet effects of aspirin.

Cite This Study

Thomason et al. (2016) studied this question.

synapsesocial.com/papers/6a22980fd5ef0a743714a198 https://doi.org/10.1111/jvim.13960

Topics

Dual antiplatelet therapy

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Implication

May attenuate cyclosporine platelet effects in dogs; hypothesis-generating, requires prospective validation before any clinical translation.

The Effects of Cyclosporine and Aspirin on Platelet Function in Normal Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The Effects of Cyclosporine and Aspirin on Platelet Function in Normal Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider