September 1, 2011Journal of Veterinary Internal MedicineOpen Access

Platelet Cyclooxygenase Expression in Normal Dogs

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Why the study?

Does aspirin alter platelet COX expression and function in normal dogs?

Population

8 female, intact hounds

Comparison

Aspirin 10 mg/kg Q12h for 10 days vs Baseline

Design

Preclinical

Follow-up

10 days

Authors

JTJohn M. ThomasonNOAA National Marine Fisheries Service KLK. LunsfordMississippi State University KMKathleen B MullinsMississippi State University

Discussion

Member takes

Implication

Aspirin exposure in normal dogs should not yet alter clinical practice; leaves open compensatory COX-1 dynamics for future translational research.

Structured PICO

Does aspirin alter platelet COX expression and function in normal dogs?

Population

8 female, intact hounds

Intervention

Aspirin 10 mg/kg Q12h for 10 days

Comparator

Baseline (before aspirin administration, repeated measures design)

Outcome

Platelet COX-1 and COX-2 expression by flow cytometry, platelet function via PFA-100, and urine 11-dehydro-thromboxane B2surrogate

Canine platelets express both COX isoforms, and aspirin exposure increases COX-1 expression despite impaired platelet function, with marked interindividual variation in COX-2 expression.

Cite This Study

Thomason et al. (2011) studied this question.

synapsesocial.com/papers/6a890d513981116ebf4d2a4c https://doi.org/10.1111/j.1939-1676.2011.00781.x

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September 1, 2011Journal of Veterinary Internal MedicineOpen Access

Platelet Cyclooxygenase Expression in Normal Dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does aspirin alter platelet COX expression and function in normal dogs?

Population

8 female, intact hounds

Comparison

Aspirin 10 mg/kg Q12h for 10 days vs Baseline

Design

Preclinical

Follow-up

10 days

Authors

JTJohn M. ThomasonNOAA National Marine Fisheries Service KLK. LunsfordMississippi State University KMKathleen B MullinsMississippi State University

Discussion

Member takes

Implication

Aspirin exposure in normal dogs should not yet alter clinical practice; leaves open compensatory COX-1 dynamics for future translational research.

Structured PICO

Does aspirin alter platelet COX expression and function in normal dogs?

Population

8 female, intact hounds

Intervention

Aspirin 10 mg/kg Q12h for 10 days

Comparator

Baseline (before aspirin administration, repeated measures design)

Outcome

Platelet COX-1 and COX-2 expression by flow cytometry, platelet function via PFA-100, and urine 11-dehydro-thromboxane B2surrogate

Canine platelets express both COX isoforms, and aspirin exposure increases COX-1 expression despite impaired platelet function, with marked interindividual variation in COX-2 expression.

Cite This Study

Thomason et al. (2011) studied this question.

synapsesocial.com/papers/6a890d513981116ebf4d2a4c https://doi.org/10.1111/j.1939-1676.2011.00781.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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