Key result
Low-dose aspirin consistently inhibited platelet function in approximately one-third of healthy dogs, despite decreased thromboxane synthesis and increased platelet COX expression.
Why the study?
Does low-dose aspirin inhibit platelet function, decrease thromboxane synthesis, and alter platelet COX expression in healthy dogs?
Population
24 healthy dogs
Comparison
Aspirin 1 mg/kg oral once daily for 10 days vs Baseline (before aspirin administration)
Design
Preclinical
Follow-up
10 days
Authors
Loading...
Warrants caution extrapolating healthy-dog data to clinical use; leaves open variable aspirin responsiveness in diseased canine populations.
Does low-dose aspirin inhibit platelet function, decrease thromboxane synthesis, and alter platelet COX expression in healthy dogs?
Effect estimate: 62% increase
p-value: p=< .001
Low-dose aspirin consistently inhibits platelet function in only about one-third of healthy dogs, despite decreased thromboxane synthesis and increased platelet COX expression.
Dudley et al. (2012) studied Healthy dogs (n=24). Low-dose aspirin vs. Baseline (before administration) was evaluated on Platelet function (PFA-100 closure time) (62% increase, p=< .001). Low-dose aspirin consistently inhibited platelet function in approximately one-third of healthy dogs, despite decreased thromboxane synthesis and increased platelet COX expression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: