Key result
Platelet function in dogs varied by breed, with higher aggregation in Cavalier King Charles Spaniels, while acetylsalicylic acid administration decreased whole-blood platelet aggregation.
Why the study?
Does breed and acetylsalicylic acid administration affect platelet function in clinically healthy dogs?
Population
45 clinically healthy dogs
Comparison
Acetylsalicylic acid 75 or 250 mg orally daily… vs Other breeds and baseline/no ASA
Design
Preclinical
Follow-up
4 days
Authors
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May guide breed-adjusted antiplatelet use in dogs; leaves open validation in diseased animals and other species.
Does breed and acetylsalicylic acid administration affect platelet function in clinically healthy dogs?
Platelet function in dogs varies by breed, and ASA effectively reduces platelet aggregation and prolongs PFA-100 closure times using Col + Epi.
Nielsen et al. (2007) studied Clinically healthy dogs (n=45). Acetylsalicylic acid (ASA) was evaluated on Platelet function assessed by whole-blood aggregation and PFA-100 closure time. Platelet function in dogs varied by breed, with higher aggregation in Cavalier King Charles Spaniels, while acetylsalicylic acid administration decreased whole-blood platelet aggregation.
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