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November 1, 2010American Journal of Veterinary Research

ULDAsp significantly delayed platelet aggregation onset with ADP at 20 μmol/L by 54% to 104%, attenuated maximum aggregation by ≥ 41%, and slowed aggregation rate by ≥ 39%, but did not alter basal or thrombin-stimulated CD62P expression.

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Why the study?

Does ultralow-dose aspirin impair platelet aggregation and alter P-selectin expression in clinically normal dogs?

Population

18 clinically normal dogs

Comparison

Ultralow-dose aspirin vs Baseline (before ULDAsp administration)

Design

Preclinical

Follow-up

24 hours after 2-day administration

Authors

KSKristopher S. SharpeJRJohn F. RandolphMBMarjory B. Brooks

Discussion

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Overview

Ultralow-dose aspirin effects in healthy dogs require validation in disease models; leaves open clinical antithrombotic utility in veterinary practice.

Structured PICO

Does ultralow-dose aspirin impair platelet aggregation and alter P-selectin expression in clinically normal dogs?

P
Population
18 clinically normal dogs
I
Intervention
Ultralow-dose aspirin (0.5 mg/kg, PO, q 24 h, for 2 days)
C
Comparator
Baseline (before ULDAsp administration)
O
Outcome
Platelet aggregation (onset, maximum response, and rate), P-selectin (CD62P) expression, and formation of platelet-leukocyte aggregatessurrogate

Ultralow-dose aspirin impairs platelet aggregation in most clinically normal dogs but does not influence CD62P platelet membrane expression.

Cite This Study

Sharpe et al. (2010) studied this question.

synapsesocial.com/papers/6a6fdcd4e36a167817e19610https://doi.org/10.2460/ajvr.71.11.1294
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen2016 · 23 citations
  2. 2The use of impedance aggregometry to evaluate platelet function after the administration of DDAVP in healthy dogs treated with aspirin or clopidogrel2021 · 5 citations
  3. 3Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs2017 · 20 citations
  4. 4Platelet function in dogs: breed differences and effect of acetylsalicylic acid administration2007 · 53 citations
  5. 5Influencing factors of ADP-induced, epinephrine-induced and ristomycin-induced platelet aggregation in dogs2008 · 5 citations