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September 23, 2021American Journal of Veterinary Research

The use of impedance aggregometry to evaluate platelet function after the administration of DDAVP in healthy dogs treated with aspirin or clopidogrel

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Why the study?

To evaluate the effect of DDAVP on platelet aggregation in healthy dogs receiving aspirin or clopidogrel.

Does DDAVP improve platelet aggregation in healthy dogs treated with aspirin or clopidogrel?

Population

7 healthy staff-owned dogs

Comparison

DDAVP treatment before vs after administration in dogs receiving aspirin or clopidogrel

Design

Randomized double-blinded crossover study

Authors

IYIgor YankinACAndy M. CarverAKAmy M. Koenigshof

Discussion

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Overview

DDAVP shows no platelet aggregometry benefit in healthy dogs on antiplatelets; leaves open efficacy in clinical bleeding or diseased models.

Structured PICO

Does DDAVP improve platelet aggregation in healthy dogs treated with aspirin or clopidogrel?

P
Population
7 healthy staff-owned dogs
I
Intervention
DDAVP (0.3 μg/kg, IV, once) administered after 4 days of aspirin (1 mg/kg, PO, q 24 h) or clopidogrel (1 mg/kg, PO, q 24 h)
C
Comparator
Baseline platelet aggregation before DDAVP administration (T1)
O
Outcome
Platelet aggregation measured by impedance aggregometry using ADP, thrombin receptor activating peptide-6, arachidonic acid, or collagen type 1surrogate

Administration of DDAVP does not appear to reverse the inhibitory effects of clopidogrel on platelet aggregation in healthy dogs.

Limitations

  • No inhibition of platelet aggregation was detected for dogs in the aspirin group, preventing conclusions regarding DDAVP in aspirin-treated dogs.

Cite This Study

Yankin et al. (2021) studied this question.

synapsesocial.com/papers/6a83fac5d65172829ee670c3https://doi.org/10.2460/ajvr.82.10.823
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of DDAVP Administrated Subcutaneously in Dogs with Aspirin-induced Platelet Dysfunction and Hemostatic Impairment due to Chronic Liver Diseases.2003 · 21 citations
  2. 2Influence of treatment with ultralow-dose aspirin on platelet aggregation as measured by whole blood impedance aggregometry and platelet P-selectin expression in clinically normal dogs2010 · 28 citations
  3. 3In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen2016 · 23 citations
  4. 4Platelet aggregometry testing during aspirin or clopidogrel treatment and measurement of clopidogrel metabolite concentrations in dogs with protein-losing nephropathy2020 · 6 citations
  5. 5Comparison of Multiplate, Platelet Function Analyzer-200, and Plateletworks in Healthy Dogs Treated with Aspirin and Clopidogrel2017 · 31 citations