Key result
Clopidogrel inhibited ADP-induced platelet aggregation in healthy dogs, decreasing it by 93% and 80% of baseline values after 72 hours in the two 3-day treatment groups.
Why the study?
Does clopidogrel inhibit platelet aggregation in healthy dogs?
Does clopidogrel inhibit platelet aggregation in healthy dogs?
Clopidogrel effectively inhibits ADP-induced platelet aggregation in healthy dogs, demonstrating similar pharmacodynamic effects to humans and supporting its use in veterinary medicine and canine models of human disease.
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Supports canine thrombosis models; leaves open translation to clinical veterinary or human applications.
Brainard et al. (2010) studied healthy dogs (n=9). Clopidogrel vs. baseline was evaluated on ADP-induced platelet aggregation. Clopidogrel inhibited ADP-induced platelet aggregation in healthy dogs, decreasing it by 93% and 80% of baseline values after 72 hours in the two 3-day treatment groups.
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