Why the study?
Does subcutaneous desmopressin improve buccal mucosal bleeding time in dogs with aspirin-induced platelet dysfunction or chronic liver disease?
Does subcutaneous desmopressin improve buccal mucosal bleeding time in dogs with aspirin-induced platelet dysfunction or chronic liver disease?
Subcutaneous desmopressin significantly shortens bleeding time in dogs with aspirin-induced platelet dysfunction, suggesting potential utility for hemostasis during invasive veterinary procedures.
Answers are grounded in this paper and cite their sources.
May aid hemostasis in aspirin-treated dogs; leaves open clinical translation and efficacy in liver disease.
To evaluate the hemostatic effects of desmopressin (DDAVP) in dogs with aspirin-induced platelet dysfunction and hemostatic impairment in chronic liver diseases, 3 microg/kg DDAVP was administrated subcutaneously. In aspirin-induced platelet dysfunction dogs (n=5), prolonged BMBT (buccal mucosal bleeding time) was shortened significantly after DDAVP injection (2.2 +/- 1.2 min, P<0.05). In dogs with chronic liver diseases (n=4), activated partial thromboplastin time (APTT) tended to shorten by 0.9 to 3.0 sec, and prolonged BMBT was shortened in two cases for 4.2 and 1.7 min after DDAVP injection. Therefore, the present results indicated that DDAVP shortened the prolonged BMBT in dogs with aspirin-induced platelet dysfunction and chronic liver disease. DDAVP might be helpful in hemostasis under invasive procedures such as biopsy or surgery for dogs with hemostatic impairment.
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Sakai et al. (2003) studied this question.
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