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March 1, 1995Seminars in Thrombosis and Hemostasis

Desmopressin Effect on Acetylsalicylic Acid Impaired Platelet Punction

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Why the study?

Does desmopressin reverse acetylsalicylic acid-induced prolonged bleeding time in healthy subjects?

Population

16 healthy subjects

Design

Other

Follow-up

48 hours

Authors

KBKarl-Heinz BeckPhillips UniversityPMPatrick MohrUniversity at Buffalo, State University of New YorkUBUlrich Bleckmann

Discussion

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Implication

Hypothesis-generating for vWF-mediated DDAVP reversal of aspirin BT; leaves open clinical translation pending trials.

Structured PICO

Does desmopressin reverse acetylsalicylic acid-induced prolonged bleeding time in healthy subjects?

P
Population
16 healthy subjects
I
Intervention
Desmopressin (DDAVP) 0.4 micrograms/kg intravenously administered 24 and 32 hours after acetylsalicylic acid (ASA) 100 mg (two doses in 12 hours)
O
Outcome
Mechanism of DDAVP's shortening of ASA prolonged bleeding times (measured by in vivo bleeding time, in vitro bleeding test, vWf, platelet aggregation, etc.)surrogate

Desmopressin shortens aspirin-prolonged bleeding time likely through the involvement of plasma von Willebrand factor and direct interaction with platelets, rather than plasma thromboxane.

Cite This Study

Beck et al. (1995) studied this question.

synapsesocial.com/papers/6a9587310cf8d0f2c97d01a3https://doi.org/10.1055/s-0032-1313600
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium1984 · 157 citations
  2. 2Effects of DDAVP Administrated Subcutaneously in Dogs with Aspirin-induced Platelet Dysfunction and Hemostatic Impairment due to Chronic Liver Diseases.2003 · 21 citations
  3. 3Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin2003 · 143 citations
  4. 4Force monitoring of clot retraction during DDAVP therapy for the qualitative platelet disorder of uraemia1991 · 25 citations
  5. 5Heparin, DDAVP and the Bleeding Time1991 · 39 citations