Why the study?
Does desmopressin alter the recruitment of platelets to endothelial cells and collagen in vitro and ex vivo?
Population
In vitro flow chamber model using resting or TRAP-activated platelets and endothelial cells, and ex vivo…
Comparison
Desmopressin 0.4 ng/ml applied to platelets… vs Untreated platelets and endothelial cells.
Design
Preclinical
Authors
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Supports indirect endothelial mechanism for desmopressin; leaves open translation to human platelet recruitment in vivo.
Does desmopressin alter the recruitment of platelets to endothelial cells and collagen in vitro and ex vivo?
DDAVP promotes platelet adhesion to collagen indirectly by inducing the release of factors like vWF from endothelial cells, which may also increase undesirable platelet-endothelial interactions.
Calmer et al. (2013) studied this question.
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