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June 30, 2017Journal of Veterinary Pharmacology and TherapeuticsOpen Access

Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs

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Why the study?

Does aspirin dose escalation identify the lowest dosage that consistently inhibits platelet function without inhibiting prostacyclin synthesis in normal dogs?

Population

8 normal dogs

Comparison

Aspirin dose escalation for 7 days each vs Pretreatment baseline

Design

Preclinical

Follow-up

7 days per dosage

Authors

NMNatalie McLeweeTATodd ArcherRWRobert W. Wills

Discussion

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Member takes

Overview

Suggests 2 mg/kg daily optimizes platelet inhibition without suppressing prostacyclin in dogs;.

Structured PICO

Does aspirin dose escalation identify the lowest dosage that consistently inhibits platelet function without inhibiting prostacyclin synthesis in normal dogs?

P
Population
8 normal dogs
I
Intervention
Aspirin dose escalation (0.5 mg/kg q24h, 1 mg/kg q24h, 2 mg/kg q24h, 4 mg/kg q24h and 10 mg/kg q12h) for 7 days each
C
Comparator
Pretreatment baseline
O
Outcome
Platelet function (aggregometry amplitude and PFA-100 closure times) and urinary 11-dehydro-thromboxane-B2 and 6-keto-prostaglandin-F1α levelssurrogate

In normal dogs, an aspirin dosage of 2 mg/kg q24h is the lowest dose that consistently inhibits platelet function without disproportionately decreasing prostacyclin synthesis.

Cite This Study

McLewee et al. (2017) studied this question.

synapsesocial.com/papers/6a8a916a51cd0cd12ac15a4dhttps://doi.org/10.1111/jvp.12432
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs2011 · 20 citations
  2. 2In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen2016 · 23 citations
  3. 3Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin2012 · 42 citations
  4. 4Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog.1980 · 17 citations
  5. 5Effects of Aspirin and Prednisone on Platelet Function and Thromboxane Synthesis in Healthy Dogs2019 · 4 citations