Why the study?
Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and whether aspirin counteracts glucocorticoid-induced hypercoagulability is unknown.
Does aspirin and/or prednisone alter platelet function and thromboxane synthesis in healthy dogs?
Population
24 healthy dogs
Comparison
Aspirin, prednisone, or prednisone/aspirin combination therapy vs placebo
Design
Randomized double-blinded study
Follow-up
28 days
Authors
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Caution against assuming platelet inhibition from thromboxane reduction in dogs; leaves open translation to clinical disease states.
Does aspirin and/or prednisone alter platelet function and thromboxane synthesis in healthy dogs?
In healthy dogs, sustained aspirin and prednisone administration decreases thromboxane synthesis but does not inhibit platelet aggregation.
Thomason et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: