Why the study?
Does ketoprofen or carprofen affect platelet function in dogs as measured by the PFA-100 analyser?
Does ketoprofen or carprofen affect platelet function in dogs as measured by the PFA-100 analyser?
Ketoprofen, but not carprofen, significantly increases platelet closure time in dogs when measured by PFA-100 with collagen-EPI stimulation.
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Carprofen at therapeutic doses does not impair canine platelet function; leaves open ketoprofen effects and clinical relevance in diseased dogs.
The effect of two nonsteroidal anti-inflammatory drugs (carprofen and ketoprofen) on platelet adhesion and aggregation functions was evaluated by the PFA-100 analyser (Dade-Behring, CA, U.S.A.) using its collagen-adenosine diphosphate (ADP) and collagen-epinephrine (EPI) cartridges. The function of platelets was evaluated in 55 healthy dogs, in 7 dogs treated with ketoprofen and in 31 dogs treated with carprofen in a therapeutic dose for minimum 5 days. The therapeutic doses of carprofen had no effect on the closure time of PFA-100 (which is the marker of platelet function) but ketoprofen caused a significant increase when using collagen-EPI stimulation The closure times for both the healthy (control) and the treated dogs using EPI cartridges were often longer than the upper default cut-off point (300 sec) of the device. The PFA-100 analyser with collagen-ADP cartridges could be a useful tool for veterinary applications including the evaluation of platelet aggregation in dogs treated with NSAIDs. The upper cut-off point of PFA-100 might be extended.
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Gaál et al. (2007) studied this question.
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