Isoindolinones, Phthalides, and a Naphthoquinone from the Fruiting Body of Daldinia concentrica

A chemical investigation of the ascomycetes of Daldinia concentrica was performed using silica gel column chromatography, ODS column chromatography, and preparative HPLC. Two new isoindolinone compounds, daldinans B ( 1 ) and C ( 2 ), two new phthalide compounds, daldinolides A ( 3 ) and B ( 4 ), and a new naphthoquinone, daldiquinone ( 5 ), were isolated together with two known compounds ( 6 and 7 ). The structures of 1, 2, and 5 were established using NMR, MS, and IR methods, and the structures of 3 and 4 were determined by derivatization from known compounds ( 6 and 7 ). 5 exhibited antiangiogenesis activity against HUVECs (IC 50 = 7.5 μM).