What question did this study set out to answer?

To investigate primary biochemical abnormalities in muscle proteins, specifically focusing on myosin, in hereditary muscular dystrophy in mice.

April 1, 1965Journal of Clinical InvestigationOpen Access

Studies of Myosin in Hereditary Muscular Dystrophy in Mice*

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Authors

MSMarvin SmollerUniversity of California, San Francisco RFRichard A. FinebergUniversity of California, San Francisco

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Implication

Directs focus to primary genetically abnormal proteins in hereditary muscular dystrophy; leaves open whether listed biochemical changes are causal or secondary.

Key Points

To investigate primary biochemical abnormalities in muscle proteins, specifically focusing on myosin, in hereditary muscular dystrophy in mice.
Review and synthesis of biochemical, tissue culture, and ultrastructural studies on dystrophic human and murine muscle tissues.
Evaluation of muscle protein catabolism, myofibril destruction, and physical properties of isolated myosin using techniques such as light scattering and ultracentrifugation.
Myofibril breakdown represents an early pathological hallmark in hereditary dystrophy, accompanied by heightened rates of muscle protein catabolism.
Isolated dystrophic myosin displays increased particle size variability and greater polydispersity relative to normal controls.

Cite This Study

Smoller et al. (1965) studied this question.

synapsesocial.com/papers/6a8d03493b974ccba12f0aa3 https://doi.org/10.1172/jci105174

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Implication

Directs focus to primary genetically abnormal proteins in hereditary muscular dystrophy; leaves open whether listed biochemical changes are causal or secondary.

Studies of Myosin in Hereditary Muscular Dystrophy in Mice*

Discussion

Member takes

Implication

Key Points

Cite This Study

Studies of Myosin in Hereditary Muscular Dystrophy in Mice*

Discussion

Member takes

Implication

Key Points

Cite This Study

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