What question did this study set out to answer?

To determine whether failure to maintain a substantial subendothelial elastin membrane drives progressive intimal thickening and atherosclerosis in large pulsatile arteries.

October 1, 1993Histopathology

The importance of a substantial elastic lamina subjacent to the endothelium in limiting the progression of atherosclerotic changes

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Population

293 subjects of all ages up to 60 years

Design

Cross-sectional

Authors

FSF. H. SimsUniversity of Auckland XCX. ChenTE Connectivity (China)JGJ.B. GavinENT and Allergy

Discussion

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Implication

Supports elastin barrier hypothesis in atherosclerosis resistance; hypothesis-generating for targeted interventions, pending prospective validation.

Key Points

To determine whether failure to maintain a substantial subendothelial elastin membrane drives progressive intimal thickening and atherosclerosis in large pulsatile arteries.
Examined and compared internal thoracic arteries and anterior descending coronary arteries from 293 subjects aged up to 60 years.
Evaluated vascular tissue sections using light microscopy, electron microscopy, and immunoperoxidase staining for macromolecules.
Internal thoracic arteries consistently developed a robust, reduplicated internal elastic lamina at early ages, showing no cellular infiltration, lipid entry, or progressive intimal thickening.
Coronary arteries demonstrated incomplete, poorly formed reduplicated internal elastic laminae alongside rapid intimal thickening and marked infiltration of lipids and macrophages.

Structured PICO

Population

293 subjects of all ages up to 60 years

Comparator

Internal thoracic arteries compared with anterior descending coronary arteries within the same individuals

Outcome

Histological differences in intimal thickening, elastic lamina formation, and entry of lipid or cells to the intimasurrogate

A robust elastin membrane subjacent to endothelial cells appears essential in limiting progressive intimal thickening and atherosclerosis.

Cite This Study

Sims et al. (1993) studied this question.

synapsesocial.com/papers/6a8d0442d8903deb3bd4f855 https://doi.org/10.1111/j.1365-2559.1993.tb01213.x

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Implication

Supports elastin barrier hypothesis in atherosclerosis resistance; hypothesis-generating for targeted interventions, pending prospective validation.

The importance of a substantial elastic lamina subjacent to the endothelium in limiting the progression of atherosclerotic changes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The importance of a substantial elastic lamina subjacent to the endothelium in limiting the progression of atherosclerotic changes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider