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A halogen- and metal-free deep eutectic solvent (DES) consisting of choline hydroxide (ChOH) and urea (1:2) was employed as a green, reusable, and cost-effective medium for the one-pot synthesis of amide derivatives from aldehydes and hydroxylamines. The DES served simultaneously as solvent and catalyst, enabling the efficient formation of a wide variety of amides. The protocol afforded biologically and medicinally relevant compounds, including nicotinamide and bebenil, in excellent yields under mild conditions.
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Mandal et al. (2026) studied this question.
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