Experimental study of afterload-reducing therapy: the effects of the reduction of systemic vascular resistance on cardiac output, aortic pressure and coronary circulation in isolated, ejecting canine hearts.

Paced, isolated, ejecting canine hearts loaded by a hydraulic system simulating systemic arterial tree input impedance

Reduction of systemic vascular resistance (Rp) under three coronary perfusion conditions: constant coronary flow, perfusion with pressure equal to mean aortic pressure (AoP), and perfusion with pressure equal to mean AoP - 30 mm Hg

Relationship between cardiac output (CO) and peripheral resistance (Rp)surrogate