Why the study?
Is the ACTN3 polymorphism associated with athletic performance level in Japanese wrestlers?
Population
378 Japanese individuals, comprising 135 wrestlers and 243 healthy controls.
Comparison
ACTN3 polymorphism (XX genotype and null X allele) vs Healthy controls and lower-tier wrestlers
Design
Case-control
Authors
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ACTN3 XX genotype was less frequent in elite wrestlers; hypothesis-generating for genetic influences on performance, requires prospective validation before any application.
Is the ACTN3 polymorphism associated with athletic performance level in Japanese wrestlers?
The ACTN3 XX genotype is underrepresented in elite Japanese wrestlers, suggesting a genetic component to high-level athletic performance in this sport.
Kikuchi et al. (2013) studied this question.
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