Key result
The ACTN3 XX genotype frequency was significantly lower in sprinters compared with controls (2.6% vs 14.5%; P=0.034), and was associated with a higher proportion of slow-twitch muscle fibres.
Population
115 subelite and elite Russian speed skaters, 60 physically active healthy men, and 1301 control subjects.
Design
Cross-sectional
Authors
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ACTN3 R577X may associate with fibre type and preferred distance in skaters; leaves open any role in selection or performance prediction.
Cross-Sectional (n=1,416)
Absolute Event Rate: 2.6% vs 14.5%
p-value: p=0.034
The ACTN3 R577X polymorphism is associated with muscle fibre type composition and preferred racing distance in speed skaters.
Ahmetov et al. (2011) conducted a cross-sectional in Healthy athletes (speed skaters) (n=1,416). ACTN3 R577X polymorphism vs. Control subjects and other genotypes was evaluated on ACTN3 XX genotype frequency in sprinters vs controls (p=0.034). The ACTN3 XX genotype frequency was significantly lower in sprinters compared with controls (2.6% vs 14.5%; P=0.034), and was associated with a higher proportion of slow-twitch muscle fibres.