Why the study?
Does Duchenne muscular dystrophy affect cerebral gray and white matter microstructure and neuropsychological performance compared to healthy controls?
Population
30 boys with Duchenne muscular dystrophy (DMD) and 22 age-matched healthy controls, age 8-18 years.
Comparison
Duchenne muscular dystrophy and subgroups based… vs Age-matched healthy controls
Design
Case-control
Authors
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Brain abnormalities may contribute to cognitive issues in DMD without changing practice; leaves open Dp140's causal role pending prospective studies.
Does Duchenne muscular dystrophy affect cerebral gray and white matter microstructure and neuropsychological performance compared to healthy controls?
Boys with Duchenne muscular dystrophy exhibit widespread cerebral gray and white matter abnormalities, with the Dp140 dystrophin isoform playing an important role in cerebral development.
Doorenweerd et al. (2014) studied this question.
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