Cardiac Sympathetic Denervation in Parkinson Disease

112 participants including 29 patients with Parkinson disease (9 with sympathetic neurocirculatory failure, 10 who had stopped receiving or had never been treated with L-dopa), 24 patients with multiple-system atrophy (17 with sympathetic neurocirculatory failure, 8 receiving L-dopa), 7 patients with pure autonomic failure, 33 controls with episodic or persistent orthostatic intolerance without sympathetic neurocirculatory failure, and 19 normal volunteers.

Frequency of cardiac sympathetic denervation and its association with disease duration, severity, and L-dopa treatmentsurrogate