Why the study?
Does phenylephrine have direct cardiac actions that confound its use in assessing baroreflex function in rats?
Population
Pentobarbitone-anaesthetised and pithed wistar rats
Design
Preclinical
Authors
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Phenylephrine should not be used for baroreflex assessment in rats; leaves open validation of alternative agents in preclinical models.
Does phenylephrine have direct cardiac actions that confound its use in assessing baroreflex function in rats?
Phenylephrine is not a useful agent for assessing baroreflex function in rats due to its direct cardiac stimulant actions.
Sawyer et al. (1986) studied this question.
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