March 1, 1986Journal of Cardiovascular Pharmacology

Age-Related Reduction of Baroreflex Tachycardia Without Loss of β-Adrenoceptor–Mediated Tachycardia in Sprague–Dawley Rats

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Why the study?

Does aging reduce baroreflex sensitivity and cardiac responsiveness in Sprague-Dawley rats?

Population

Young (3-7 months) and old (21-24 months) Sprague-Dawley rats

Comparison

Administration of nitroprusside, isoprenaline… vs Young (3-7 months) versus old (21-24 months) rats

Design

Preclinical

Authors

JDJames R. DochertyRoyal College of Surgeons in Ireland DFDesmond J. FitzgeraldCross-Cutting Cardiology KOK O'MalleyJohns Hopkins University

Discussion

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Implication

Baroreflex decline with aging occurs without reduced cardiac responsiveness in rats; hypothesis-generating for autonomic changes in older adults.

Structured PICO

Does aging reduce baroreflex sensitivity and cardiac responsiveness in Sprague-Dawley rats?

Population

Young (3-7 months) and old (21-24 months) Sprague-Dawley rats

Intervention

Administration of nitroprusside, isoprenaline, noradrenaline, and single-pulse electrical stimulation

Comparator

Young (3-7 months) versus old (21-24 months) rats

Outcome

Baroreflex sensitivity (slope of regression line for fall in diastolic blood pressure against resultant tachycardia) and cardiac responsiveness (tachycardia produced by isoprenaline, noradrenaline, and electrical stimulation)surrogate

Aging reduces baroreflex sensitivity in rats, but this reduction is not caused by a decreased responsiveness of the heart to β-adrenoceptor stimulation.

Cite This Study

Docherty et al. (1986) studied this question.

synapsesocial.com/papers/6a912dede45072ae4a2e4e64 https://doi.org/10.1097/00005344-198603000-00021

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Implication

Baroreflex decline with aging occurs without reduced cardiac responsiveness in rats; hypothesis-generating for autonomic changes in older adults.

Age-Related Reduction of Baroreflex Tachycardia Without Loss of β-Adrenoceptor–Mediated Tachycardia in Sprague–Dawley Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Age-Related Reduction of Baroreflex Tachycardia Without Loss of β-Adrenoceptor–Mediated Tachycardia in Sprague–Dawley Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider