Key result
Elderly hypertensive patients demonstrated significantly impaired heart rate baroreflex responses to nitroprusside-induced blood pressure reduction compared to young hypertensives (p<0.01).
Why the study?
Is baroreflex function impaired in elderly hypertensive patients compared to young hypertensives and young normotensives?
Population
27 subjects including 10 elderly hypertensive patients, 10 young hypertensives, and 7 young normotensive…
Comparison
Intravenous nitroprusside infusion to reduce… vs Young hypertensives and young normotensives
Design
Cross-sectional
Authors
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Impaired baroreflex responses may alter vasodilator effects in elderly hypertensives; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=27)
Is baroreflex function impaired in elderly hypertensive patients compared to young hypertensives and young normotensives?
p-value: p=<0.01
The heart rate component of the baroreflex is impaired in elderly hypertensive patients, suggesting their clinical response to antihypertensive drugs may be altered.
McGarry et al. (1983) conducted a cross-sectional in Hypertension (n=27). Elderly age with hypertension vs. Young hypertensives and young normotensives was evaluated on Heart rate increases in the erect position and slope of regression line relating change in blood pressure with change in R-R interval (p=<0.01). Elderly hypertensive patients demonstrated significantly impaired heart rate baroreflex responses to nitroprusside-induced blood pressure reduction compared to young hypertensives (p<0.01).
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