What question did this study set out to answer?

To determine how baseline blood pressure, age, and baroreflex sensitivity influence the vasodepressor response to sodium nitroprusside in patients with essential hypertension.

September 1, 1984Journal of Cardiovascular Pharmacology

Age and Blood Pressure Determine Vasodepressor Response to Sodium Nitroprusside

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Why the study?

What are the determinants of the vasodepressor response to sodium nitroprusside in patients with uncomplicated essential hypertension?

Population

22 patients, aged 33-72 years, with uncomplicated essential hypertension

Design

Other

Follow-up

10 min duration per infusion

Authors

NINorman A. IrvineNinewells Hospital ASAlexander M. M. ShepherdThe University of Texas Health Science Center at San Antonio

Discussion

Member takes

Implication

Baseline BP may guide nitroprusside dosing in hypertension; leaves open distinct mechanisms for age- versus hypertension-related baroreflex impairment.

Key Points

To determine how baseline blood pressure, age, and baroreflex sensitivity influence the vasodepressor response to sodium nitroprusside in patients with essential hypertension.
Administered sequential incremental intravenous infusions of sodium nitroprusside in 10-minute intervals to 22 patients aged 33–72 years with uncomplicated essential hypertension.
Measured changes in mean arterial pressure, heart rate, and plasma norepinephrine at the end of each infusion period.
Calculated dose-response slopes and baroreflex sensitivity from the relationship between changes in heart rate and mean arterial pressure.
Dose-response curve slopes were directly proportional to predrug blood pressure (p < 0.0001) and inversely proportional to baroreflex sensitivity (p = 0.0007).
Baroreflex sensitivity was inversely proportional to, and equally dependent on, predrug blood pressure and age (p = 0.0116).
Predrug blood pressure accounted for approximately 75% of the variability in the dose-response slope, whereas age accounted for 25%.

Structured PICO

What are the determinants of the vasodepressor response to sodium nitroprusside in patients with uncomplicated essential hypertension?

Population

22 patients, aged 33-72 years, with uncomplicated essential hypertension

Intervention

Sequential incremental intravenous infusions of sodium nitroprusside, each of 10 min duration

Outcome

Changes in mean arterial pressure (delta MAP), heart rate (delta HR), and plasma norepinephrine (delta nc) at the end of each infusion periodsurrogate

The vasodepressor response to sodium nitroprusside is primarily determined by predrug blood pressure rather than age, suggesting different mechanisms for age- and hypertension-related reductions in baroreflex sensitivity.

Cite This Study

Irvine et al. (1984) studied this question.

synapsesocial.com/papers/6a7d3de22935e92dbc775e31 https://doi.org/10.1097/00005344-198409000-00012

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Implication

Baseline BP may guide nitroprusside dosing in hypertension; leaves open distinct mechanisms for age- versus hypertension-related baroreflex impairment.

Age and Blood Pressure Determine Vasodepressor Response to Sodium Nitroprusside

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Age and Blood Pressure Determine Vasodepressor Response to Sodium Nitroprusside

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider