Why the study?
Do sodium nitroprusside and hydralazine have different hemodynamic and sympathoadrenal effects in subjects with uncomplicated essential hypertension?
Population
18 subjects with uncomplicated essential hypertension
Comparison
Intravenous sodium nitroprusside vs Bolus injections of hydralazine (0.05-0.3 mg/kg)
Design
Other
Authors
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May guide vasodilator selection by hemodynamic profile in hypertension; leaves open whether combinations optimize outcomes in prospective trials.
Do sodium nitroprusside and hydralazine have different hemodynamic and sympathoadrenal effects in subjects with uncomplicated essential hypertension?
Sodium nitroprusside and hydralazine elicit markedly different hemodynamic and sympathoadrenal responses in hypertensive patients, suggesting a combination approach might optimize hypotensive effects while minimizing adverse hemodynamic profiles.
Shepherd et al. (1986) studied this question.
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