Why the study?
Does captopril pre-treatment accentuate the hypotensive effect of sodium nitroprusside in normal subjects?
Population
6 normal subjects
Comparison
Graded intravenous infusions of sodium… vs Graded intravenous infusions of sodium…
Design
Other
Authors
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Captopril may potentiate nitroprusside hypotension in normals; leaves open need for dose adjustment in patients.
Does captopril pre-treatment accentuate the hypotensive effect of sodium nitroprusside in normal subjects?
Combined use of captopril and arterial vasodilators like sodium nitroprusside requires a reduction in the dose of the vasodilator to avert severe hypotension.
Jennings et al. (1981) studied this question.
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