Why the study?
Does captopril pretreatment alter the plasma noradrenaline response to sodium nitroprusside in normal volunteers?
Population
6 normal volunteers (normotensive, salt replete)
Comparison
Pretreatment with captopril followed by infusion… vs Pretreatment with placebo followed by infusion…
Authors
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Captopril pretreatment leaves sympathetic and hemodynamic responses to nitroprusside unaltered in normotensives; confirms normal angiotensin II lacks tonic control of noradrenaline release.
Does captopril pretreatment alter the plasma noradrenaline response to sodium nitroprusside in normal volunteers?
In normotensive humans, normal levels of angiotensin II do not appear to exert a tonic regulatory effect on noradrenaline release.
Becker et al. (1986) studied this question.
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