Population
Conscious old (24 mo) and young (10 wk) Wistar rats
Comparison
Aging (24 months old) vs Young (10 weeks old) Wistar rats
Design
Preclinical
Authors
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Animal data on age-related baroreflex impairment warrant clinical caution; extends preclinical models but leaves human translation open.
Aging in rats is associated with impaired baroreflex control of heart rate and renal sympathetic nerve activity, despite preserved baseline blood pressure and heart rate.
Irigoyen et al. (2000) studied this question.
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