October 8, 1999Biochemical JournalOpen Access

Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages

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Population

Mouse peritoneal macrophages (MPM) from normal mice and induced mutant mice that lack LPL expression

Comparison

Endogenous expression of lipoprotein lipase (LPL) vs Lack of LPL expression (mutant mice)

Design

Preclinical

Authors

XWXiaosong WangNovartis (United States)JGJoachim GreilbergerMedical University of Graz SLSanja Levak‐FrankMedical University of Graz

Discussion

Member takes

Implication

Macrophage LPL may promote foam cell formation; hypothesis-generating in animal models and leaves open human relevance.

Structured PICO

Population

Mouse peritoneal macrophages (MPM) from normal mice and induced mutant mice that lack LPL expression

Intervention

Endogenous expression of lipoprotein lipase (LPL)

Comparator

Lack of LPL expression (mutant mice)

Outcome

Cell binding and uptake of Eu(3+)-labelled native and oxidized LDLsurrogate

Macrophage-produced LPL facilitates the uptake of native and mildly/moderately oxidized LDL, suggesting a mechanism for foam cell formation in atherosclerosis.

Cite This Study

Wang et al. (1999) studied this question.

synapsesocial.com/papers/6a8d0f418ed61d1c568e4e16 https://doi.org/10.1042/bj3430347

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Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider