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Skin biopsies from six patients with chronic Trichophyton rubrum infection were screened for HLA-DR, adhesion molecule expression and lymphocyte markers. Five showed reduced keratinocyte labelling for the intercellular adhesion molecule, ICAM-1, in the presence of HLA-DR. These findings suggest an in situ modulation of the cellular immune response.
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Schechtman et al. (1993) studied this question.
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