Why the study?
Is there a relationship between circulating melatonin levels and global longitudinal strain in patients with STEMI?
Is there a relationship between circulating melatonin levels and global longitudinal strain in patients with STEMI?
Circulating melatonin levels are negatively correlated with global longitudinal strain in patients with STEMI, suggesting a potential link between melatonin and myocardial deformation.
Association in STEMI is hypothesis-generating; leaves open causal role or therapeutic implications.
Low circulating melatonin levels predict poor outcome in patients with ST-segment elevation myocardial infarction (STEMI). In the present study, we investigated whether a relationship between myocardial deformation in parameters measured by echocardiography and circulating melatonin level exists. We prospectively included 112 patients with STEMI who performed echocardiography and simultaneous measurement of serum melatonin, during the light period within 72 h of admission. We found a negative correlation between circulating melatonin levels and global longitudinal strain (p = 0.006, r = -0.33). In conclusion, melatonin levels have a correlation with two-dimensional speckle tracking in patients with STEMI.
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Domínguez‐Rodríguez et al. (2013) studied this question.
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