Biochemical analysis reveals an apurinic site-specific endonuclease in rat liver tissue, suggesting evolutionary conservation of DNA repair mechanisms between mammals and bacteria.
Rat liver contains an endonuclease which breaks DNA strands near apurinic sites. The purified enzyme is strictly specific for apurinic sites; it has no action on DNA normal strands, or on strands carrying alkylated sites. These properties are identical to those of the Escherichia coli endonuclease for depurinated DNA.
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Verly et al. (1973) studied this question.
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