Why the study?
Does AT1R expression in placental tissue differ in women with pre-eclampsia with and without IUGR compared to normal pregnancies?
Does AT1R expression in placental tissue differ in women with pre-eclampsia with and without IUGR compared to normal pregnancies?
Altered AT1R expression in placental tissue is associated with pre-eclampsia and intrauterine growth restriction, suggesting its role in normal fetal growth and pregnancy course.
OBJECTIVE: The aim of this study was to examine and compare the localization and immunoreactivity of the angiotensin type-1 receptor (AT1R) in human placental tissue in patients with pregnancy complicated by pre-eclampsia with and without intrauterine growth restriction (IUGR). METHODS: Immunohistochemistry was used to examine the localization of the AT1R in human placental tissue. Semiquantitative immunohistochemical H-score values for each placental cell type were calculated. RESULTS: Elevated H-score index values for decidual cells, syncytiotrophoblast and cytotrophoblast in pre-eclamptic patients were found to be higher in comparison with values in the control group. Decreased H-score index values for syncytiotrophoblast and cytotrophoblast were found in patients with pregnancy complicated by IUGR in the course of pre-eclampsia. CONCLUSIONS: The results obtained in this study point out the significant role of the AT1R and suggest that normal AT1R activity is of fundamental significance for the normal course of pregnancy and proper fetal growth.
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Laskowska et al. (2004) studied this question.
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