Monte-Carlo computer simulation of random strand breakage has been applied to analysis of alkaline sucrose gradient sedimentation profiles from irradiated DNA. The method is simple and widely applicable, is valid at all radiation doses and for all size distributions of the unirradiated DNA. The data is efficiently utilized, resulting in improved accuracy in determining the efficiency of strand breakage. The analysis provides two tests of conformity of experimental data to the expected breakage and sedimentation behavior.
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Gillespie et al. (1972) studied this question.
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