Why the study?
Do pharmacological or nonpharmacological approaches prevent acute kidney injury in children undergoing cardiac surgery?
Do pharmacological or nonpharmacological approaches prevent acute kidney injury in children undergoing cardiac surgery?
Early peritoneal dialysis and targeting modifiable risk factors are effective in preventing acute kidney injury in children undergoing cardiac surgery, whereas routine pharmacological approaches lack strong evidence.
Children undergoing cardiac surgery are at risk of developing acute kidney injury (AKI). Preventing cardiac surgery-associated AKI (CS-AKI) is important as it is associated with increased early- and long-term mortality and morbidity. Targeting modifiable risk factors (eg, avoiding poor renal perfusion, nephrotoxic drugs, and fluid overload) reduces the risk of CS-AKI. There is currently no strong evidence for the routine use of pharmacological approaches (eg, aminophylline, dexmedetomidine, fenoldopam, and steroids) to prevent CS-AKI. There is robust evidence to support the role of early peritoneal dialysis as a nonpharmacologic approach to prevent CS-AKI.
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Leow et al. (2018) studied this question.
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