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The first boranophosphorothioate [(RO)2P(S)(BH3)–] mimic of a phosphodiester compound, dithymidine boranophosphorothioate, has been synthesized; while it is water soluble, this new analogue is more lipophilic and nuclease resistant than natural nucleoside phosphodiesters [(RO)2P(O)(O)–] and phosphorothioates [(RO)2P(S)(O)–].
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Lin et al. (1999) studied this question.
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