Glucose Consumption by the Perfused, Isolated Rat Liver

It is shown that the perfusion of an isolated liver is a suitable and useful technique for distinguishing and investigating liver function per se. Steady state conditions were used to determine net glucose consumption by the liver. The results indicate a linear relation exists between blood glucose level and net glucose consumption by the isolated, perfused liver. Net glucose consumption was achieved at blood glucose levels as low as 100 mg/100 ml.