Population
In vitro biochemical model studying elongation factor 1alpha, F-actin, and aminoacyl-tRNA
Design
Preclinical
Authors
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May link pH to cytoskeletal translation control; hypothesis-generating for in vivo validation in animal models.
The study demonstrates that pH regulates the mutually exclusive binding of EF-1alpha to F-actin and aa-tRNA, suggesting a mechanism for localizing translation machinery to the cytoskeleton.
Liu et al. (1996) studied this question.
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