Renal Failure with Cirrhosis

Article1 June 1966Renal Failure with CirrhosisObservations on the Role of DiureticsFRED L. LIEBERMAN, M.D., TELFER B. REYNOLDS, M.D., F.A.C.P.FRED L. LIEBERMAN, M.D.Search for more papers by this author, TELFER B. REYNOLDS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the paper of Hecker and Sherlock (1) in 1956, renal failure developing in a setting of cirrhosis with ascites has received increasing attention (2-4). It is distinguished by the lack of such precipitating factors as gastrointestinal hemorrhage, sepsis with shock, and common renal and hepatic toxins or infectious agents known to induce renal failure. Because of the lack of consistent histologic renal abnormalities, Vesin (5) has used the term "functional" to describe this renal failure. Although it is possible that functional renal failure has been partially overlooked in the past and its true prevalence underestimated, it is also possible...References1. HECKERSHERLOCK RS: Electrolyte and circulatory changes in terminal liver failure. Lancet 2: 1121, 1956. CrossrefGoogle Scholar2. PAPPERBELSKYBLEIFER SJLKN: Renal failure in Laennec's cirrhosis of the liver. Ann. Intern. Med. 51: 759, 1959. LinkGoogle Scholar3. SUMMERSKILLCLOWDUSCASEY WHBFTH: Clinical and metabolic changes during the development of azotemia in hepatic failure with ascites. Mayo Clin. Proc. 35: 783, 1960. Google Scholar4. BALDUSFEICHTERSUMMERSKILL WPRNWH: I. Clinical and biochemical features of azotemia in hepatic failure. Ann. Intern. Med. 60: 353, 1964. LinkGoogle Scholar5. VESIN P: Late functional renal failure in cirrhosis with ascites: pathophysiology, diagnosis and treatment, in Aktuelle Probleme der Hepatologie, edited by MARTINI, G. A. Georg Thieme Verlag, Stuttgart, 1962, pp. 98-109. Google Scholar6. CALVINDECHERDHERMANN DBGG: Response of plasma volume to diuretics. Proc. Soc. Exp. Biol. Med. 44: 529, 1940. CrossrefGoogle Scholar7. PEQUIGNOTPEQUIGNOTCAROLI GEJ: Effets toxiques retardes après traitement d'ascites cirrhotiques par la chlorothiazide. Sem. Hop. Paris 36: 1801, 1960. Google Scholar8. PEQUIGNOTCOMBRISSONVIALLETCAROLI GAAJ: Hypovolemie relative des cirrhotiques avec hyperazotemia. Arch. Mal. Appar. Dig. 51: 744, 1962. MedlineGoogle Scholar9. EVENNICOLLOBENHAMOUFAUVERT PFJPR: Effets des diuretiques sur le debit cardique dans les cirrhoses du foie. Soc. Med. Hop. Paris 114: 1285, 1963. MedlineGoogle Scholar10. BONSNESTAUSSKY RWHN: On colorimetric determination of creatinine by the Jaffe reaction. J. Biol. Chem. 158: 581, 1945. CrossrefGoogle Scholar11. SMITH HW: Principles of Renal Physiology. Oxford University Press, New York, 1956. Google Scholar12. LIEBERMANREYNOLDS FLTB: Plasma volume in cirrhosis of the liver (abstract). Clin. Res. 14: 136, 1966. Google Scholar13. EISENMENGER WJ: Role of sodium in the formation and control of ascites in patients with cirrhosis. Ann. Intern. Med. 37: 261, 1952. LinkGoogle Scholar14. PAPPER S: The role of the kidney in Laennec's cirrhosis of the liver. Medicine (Balt.) 37: 299, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, CaliforniaFrom the Hepatic Service of the John Wesley County Hospital, Los Angeles, and the Department of Medicine of the University of Southern California, Los Angeles, Calif.This study was supported in part by research grants HE-01718 and HE-09316-01, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Telfer B. Reynolds, M.D., Department of Medicine, University of Southern California School of Medicine, 2025 Zonal Ave., Los Angeles, Calif. 90033. 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MCCLOY, M.D., WILLIAM P. BALDUS, M.D., W. NEWLON TAUXE, M.D., W. H. J. SUMMERSKILL, M.D., F.A.C.P. 1 June 1966Volume 64, Issue 6Page: 1221-1228KeywordsAscitesBlood plasmaCirrhosisHospital medicineIngestionRenal failureResearch grantsSepsisShockToxins Issue Published: 1 June 1966 PDF DownloadLoading ...