Population
Pressurized uterine arteries from nonpregnant (NPUA) and near-term pregnant (PUA) sheep
Comparison
Pregnancy and pharmacological modulation vs Nonpregnant sheep uterine arteries (NPUA)
Design
Preclinical
Authors
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May inform gestational vascular adaptation mechanisms in animal models; leaves open human relevance and clinical translation.
Pregnancy attenuates pressure-dependent myogenic tone in the uterine artery by decreasing Ca2+ sensitivity via increased MEK/ERK activity and decreased PKC signaling.
Xiao et al. (2006) studied this question.
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