Why the study?
Does 4-aminopyridine restore blood pressure and improve survival in a rat model of anaphylactic shock?
Does 4-aminopyridine restore blood pressure and improve survival in a rat model of anaphylactic shock?
In a rat model of anaphylactic shock, 4-aminopyridine restored blood pressure and improved survival, suggesting potential utility as an adjunctive therapy for refractory anaphylactic shock.
Should not yet change anaphylaxis management; leaves open translation of 4-aminopyridine to refractory human shock.
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Bellou et al. (2016) studied this question.
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