Population
Single myocytes of guinea pig vas deferens, ureter, and proximal colon, and rabbit vas deferens, as well as…
Design
Preclinical
Authors
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AA selectively blocks A-type K+ currents in vascular smooth muscle but not atrial myocytes in animals; leaves open translation to human channel pharmacology or therapy.
Arachidonic acid directly blocks A-type K+ channels in smooth muscle cells but not in atrial myocytes, indicating structural or functional differences between these channel types.
Nagano et al. (1997) studied this question.
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