What question did this study set out to answer?

To determine whether venous unstressed volume, compliance, and wall distensibility are structurally modified in primary hypertension.

Structurally reduced distensibility of cardiovascular ‘low‐pressure’ compartments in primary hypertension, as studied in spontaneously hypertensive rats (SHR)

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Rat model suggests venous structural changes in hypertension; leaves open translation to human primary hypertension.

To determine whether venous unstressed volume, compliance, and wall distensibility are structurally modified in primary hypertension.
Compared adult male spontaneously hypertensive rats (SHR) with normotensive Wistar Kyoto rats (WKY).
Evaluated initial volumes and pressure-volume characteristics across maximally vasodilated hindquarters and entire, completely relaxed cardiovascular systems during cardiac arrest.
Extrapolated unstressed venous volumes at zero pressure were identical between SHR and WKY in both preparations.
Venous compliance (delta V/delta P) was reduced by approximately 20% in SHR across both experimental models.
Structurally determined wall distensibility in low-pressure compartments was significantly decreased by about 10% in SHR.

Haraldsson et al. (1981) studied this question.

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